Top 5 Supplements for Women 40 and Older to Support Wellness, Fitness, and Healthy Living

Between managing careers, families, and personal goals, women in their 40s (and even mid-30s) and beyond constantly navigate life transitions—from hormonal shifts to energy, mood, and metabolism changes. At Moore Wellness Solutions, we believe optimal women’s health starts with understanding your body’s needs, and supplementing with high-quality, research-backed medical-grade supplements is one of the smartest ways to support your overall wellness and fitness journey.

Unlike most over-the-counter options, professional-grade supplements are manufactured with strict quality control and clinically tested ingredients, ensuring your body can actually absorb and use what you’re giving it.

Here are the top 5 supplements women over age 40 should consider for long-term vitality, hormone balance, mental clarity, and healthy aging:

1. Vitamin D3 with K2: A Foundational Wellness Boost

Vitamin D3 combined with Vitamin K2 plays a crucial role in women’s health and fitness, especially as we age. This dynamic duo supports:

Strong bones and joints
Balanced mood and mental health
Healthy hormones and metabolism
Robust immune function
Radiant skin and heart health

Before supplementing, it’s essential to check your vitamin D levels. While lab ranges may list 30–100 ng/mL as “normal,” we aim for optimal levels between 70–80 ng/mL.

A good rule of thumb: 10,000 IU daily for 30 days can raise levels by about 10 points—but dosing should always be guided by a healthcare provider.

2. Creatine: Not Just for Athletes

Contrary to common belief, creatine isn’t just for bodybuilders. Women, especially over age 40, naturally have lower creatine stores and can benefit greatly from supplementing, whether or not you’re an avid gym-goer.

Creatine supports:

Muscle strength and recovery during workouts
Fat reduction and healthy body composition
Hormonal balance through menstruation, pregnancy, and menopause
Cognitive function, mental clarity, and mood stability

We recommend 5g of creatine daily, mixed in 8 oz of water, as part of a well-rounded women’s fitness and wellness routine.

Our go-to: Metagenics Creatine UP – clean, effective, and science-backed.

3. Vitamin B12: For Energy, Brain Health & More

As we age, our ability to absorb Vitamin B12 naturally declines, especially for women over 40. B12 is critical for energy production, brain function, and metabolic health.

Why it’s essential:

Promotes healthy red blood cells and prevents certain types of anemia
Boosts energy, mood, and mental clarity
Protects against memory loss and cognitive decline
Supports bone density and metabolism

Many labs list a wide range (200–1100 pg/mL), but we see optimal health when levels are closer to 700-900 pg/mL.

We recommend methylated B12 (methylcobalamin) for best absorption, as many women have trouble converting the inactive form, cyanocobalamin.

Trusted options:

Pure Encapsulations Liquid B12
Metagenics MethylCare

4. Magnesium: A Must-Have for Stress, Sleep, and Hormone Health

One of the most versatile and underrated minerals for women’s health, magnesium supports nearly every system in the body, especially during the stress-heavy decades of life.

Magnesium benefits include:

Improved sleep quality and muscle relaxation
Reduced anxiety, irritability, and cortisol levels
Relief from PMS symptoms like cramps and bloating
Fewer or less intense migraines
Better bowel regularity and digestive health
Increased bone density and improved blood sugar regulation

There are various types of magnesium (glycinate, citrate, oxide, taurate, malate, sulfate), each offering specific benefits. A wellness provider can help you choose the right one based on your unique needs.

5. Why Nutraceuticals Beat Over-the-Counter Supplements Every Time

Let’s face it—most store-bought vitamins don’t meet the quality standards required for real health improvements. At Moore Wellness Solutions, we only recommend reputable nutraceutical brands that are:

Clinically tested and research-supported
Made with high-quality, bioavailable ingredients
Produced under strict quality control and safety standards
Proven to be more effective and better absorbed by your body

Choosing professional-grade supplements is an investment in your long-term health, hormone balance, and wellness outcomes.

Building Your Personalized Supplement Plan

If you’re a woman 40 and over, now is the time to take charge of your health, fitness, and overall wellness. These five foundational supplements can support everything from hormonal health and mental clarity to physical energy and emotional resilience.

But remember, supplementation should be personalized. At Moore Wellness Solutions, we offer expert guidance to help you find exactly what your body needs to thrive during every stage of womanhood.

Book a consultation with Moore Wellness Solutions today, and let’s build your personalized wellness plan together.

Rejuvenate. Recharge. Redefine.

This information is for informational/educational purposes only and does not replace professional medical advice for your individual symptoms and is not intended to be used for diagnosis of a specific medical condition or treatment recommendation. Always consult your licensed healthcare provider for concerns about your health.